50.18.212.88 (EC2-50-18-212-88.US-WEST-1.COMPUTE.AMAZONAWS.COM)
A total of 3 sites are hosted on 50.18.212.88.
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her2treatment.com
Learn about possible HER2+ breast cancer treatments, and which may be right for you based on which stage of breast cancer you have.
avastin-hcp.com
Learn about Avastin® (bevacizumab) for FDA approved indications. Avastin is indicated for the treatment of glioblastoma as a single agent for adult patients with progressive disease following prior therapy. The effectiveness of Avastin in glioblastoma is based on an improvement in objective response rate. There are no data demonstrating an improvement in disease‐related symptoms or increased survival with Avastin. Avastin is indicated for the first‐ or second‐line treatment of patients with metastatic carcinoma of the colon or rectum in combination with intravenous 5‐fluorouracil–based chemotherapy. Avastin, in combination with fluoropyrimidine‐irinotecan‐ or fluoropyrimidine‐oxaliplatinbased chemotherapy, is indicated for the second‐line treatment of patients with metastatic colorectal cancer who have progressed on a first‐line Avastin‐containing regimen. Limitation of Use: Avastin is not indicated for adjuvant treatment of colon cancer. Avastin is indicated for the first‐line treatment of unresectable, locally advanced, recurrent or metastatic non–squamous non–small cell lung cancer in combination with carboplatin and paclitaxel. Avastin is indicated for the treatment of metastatic renal cell carcinoma in combination with interferon alfa. Avastin in combination with paclitaxel and cisplatin or paclitaxel and topotecan is indicated for the treatment of persistent, recurrent, or metastatic carcinoma of the cervix. Avastin in combination with paclitaxel, pegylated liposomal doxorubicin or topotecan is indicated for the treatment of patients with platinum‐resistant recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer who received no more than 2 prior chemotherapy regimens. BOXED WARNINGS: Gastrointestinal (GI) perforation: Serious and sometimes fatal GI perforation occurs at a higher incidence in Avastin‐treated patients compared to controls. The incidences of GI perforation ranged from 0.3% to 3.2% across clinical studies. Discontinue Avastin in patients with GI perforation. Surgery and wound healing complications: The incidence of wound healing and surgical complications, including serious and fatal complications, is increased in Avastin‐treated patients. Do not initiate Avastin for at least 28 days after surgery and until the surgical wound is fully healed. The appropriate interval between termination of Avastin and subsequent elective surgery required to reduce the risks of impaired wound healing/wound dehiscence has not been determined. Discontinue Avastin at least 28 days prior to elective surgery and in patients with wound healing complications requiring medical intervention. Hemorrhage: Severe or fatal hemorrhage, including hemoptysis, GI bleeding, hematemesis, central nervous system hemorrhage, epistaxis, and vaginal bleeding, occurred up to 5‐fold more frequently in patients receiving Avastin. Across indications, the incidence of grade ≥3 hemorrhagic events among patients receiving Avastin ranged from 0.4% to 6.9%. Do not administer Avastin to patients with serious hemorrhage or recent hemoptysis (≥1/2 tsp of red blood). Discontinue Avastin in patients with serious hemorrhage (ie, requiring medical intervention). ADDITIONAL SERIOUS ADVERSE EVENTS: Additional serious and sometimes fatal adverse events with increased incidence in the Avastin‐treated arm vs control included: GI fistulae (up to 2% in metastatic colorectal cancer and ovarian cancer patients). Non‐GI fistulae (<1% in trials across various indications; 1.8% in a cervical cancer trial). Arterial thromboembolic events (grade ≥3, 2.6%). Proteinuria (nephrotic syndrome, <1%). Additional serious adverse events with increased incidence in the Avastin‐treated arm vs control included: GI‐vaginal fistulae occurred in 8.3% of patients in a cervical cancer trial. Venous thromboembolism (grade 3–4, up to 10.6%) in patients with persistent, recurrent, or metastatic cervical cancer treated with Avastin. Hypertension (grade 3–4, 5%–18%). Posterior reversible encephalopathy syndrome (PRES) (<0.5%). Infusion reactions with the first dose of Avastin were uncommon (<3%), and severe reactions occurred in 0.2% of patients. Inform females of reproductive potential of the risk of ovarian failure prior to starting treatment with Avastin. Avoid use in patients with ovarian cancer who have evidence of recto‐sigmoid involvement by pelvic examination or bowel involvement on CT scan or clinical symptoms of bowel obstruction. PREGNANCY WARNING: Based on the mechanism of action and animal studies, Avastin may cause fetal harm. Advise female patients that Avastin may cause fetal harm, and to inform their healthcare provider of a known or suspected pregnancy. Advise females of reproductive potential to use effective contraception during treatment with Avastin and for 6 months after the last dose of Avastin. Advise nursing women that breastfeeding is not recommended during treatment with Avastin. Avastin may impair fertility. MOST COMMON ADVERSE EVENTS: Across indications, the most common adverse reactions observed in Avastin patients at a rate >10% and at least twice the control arm rate were: epistaxis, headache, hypertension, rhinitis, proteinuria, taste alteration, dry skin, rectal hemorrhage, lacrimation disorder, back pain, exfoliative dermatitis. Across all studies, Avastin was discontinued in 8.4% to 21% of patients because of adverse reactions. You may report side effects to the FDA at (800) FDA‐1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835‐2555. Please see accompanying full Prescribing Information, including BOXED WARNINGS, for additional important safety information.
genentech-access.com
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